AIMMS mini symposium




2020-10-02 AIMMS mini symposium

STAR PLUS PhD students

Amsterdam Institute of Molecular and Life Sciences


Conference / Symposium / Seminar

During the online mini symposium AIMMS's STAR PLUS PhD students will give an update on their ongoing research projects. The PhD students all work in the field of antibiotic resistance and development. They are trying to increase the understanding of resistance development and to find new antibiotic targets.

 10.00 – 10.30    Felix Paulussen
 10.30 – 11.00    Priyaka Chauhan
 11.00 – 11.15    Mini break
 11.15 – 11.45    Alicia Berkvens

felix paulussen png

Priyanka Chauhan PhD student:
Development of molecular strategies to quantify the dormant and active state of mycobacteriumpriyanka chauhan
The presence of subpopulation of non-growing, or dormant cells during tuberculosis infections is an immense problem. These cells persist antibiotic treatment and hence, cause treatment failure and recalcitrant infections. Since, these cells are present in very small number, their isolation and study become very difficult. I will present a simple dye-based detection and isolation technique for persisters, which can be utilized to quantify persister subpopulations of mycobacteria.

Alicia Berkvens PhD student: Exploring the Link Between Growth Regulation and Persister Formation alicia berkvens
About 1 in 10^4 cells in an E. coli population has switched to a non-growing persister phenotype. These cells don’t grow, but can withstand harsh stresses. So when a population is faced with a stressor killing all growing cells, persisters will survive and when they switch back to the normal phenotype they can form a growing population again. Since persisters can survive antibiotic treatment, they have an increased risk of obtaining antibiotic resistance mutations. To combat the resistance crisis it is thus crucial to understand how these persisters are formed. How is it possible that from an isogenic population of cells, all exposed to the same conditions, some will switch to a dormant state? Through small computational models I explore this question and I will share how persister formation is linked to E. coli’s growth regulation.

Meeting link
Topic: COFUND mini symposium
Time: Oct 2, 2020 10:00 AM Amsterdam

Join Zoom Meeting

If you would like to attend the mini symposium, you can send an email to: The access code will be sent to you by email.

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This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 713669.