The mission of the Systems Bioinformatics research group is to advance science, medicine and biotechnology, through the understanding of the physiology of unicellular principles in terms of design principles of the underlying biological networks. The focus lies on a number of model organisms, including Lactococcus lactis, Saccharomyces cerevisiae, Paracoccus denitrificans and Escherichia coli. However, their research interests in physiology and regulation of metabolism transcend specific organisms.
Design principles are a set of rules that link systems specifications (the function of the design and constraints acting on it) to biological implementations (designs). Most biological functions emerge from the interactions of biological components, either intracellular ones or with cells as components. We study this emergence, and its chance and necessity. Research lines of the Systems Bioinformatics group include:
- Genome-scale metabolic reconstructions and models used for the global picture and integration of high-throughput data;
- Self-replicating models: modular models able to capture trade-offs in whole cells that govern growth strategies in unicellular organisms;
- Detailed kinetic models of subsystems.