Chemical stabilization of peptide secondary and tertiary structures
To modulate the secondary structure of synthetic peptides, non-natural amino acids are introduced. The design process involves building block and solid-phase peptide synthesis as well as biophysical characterization of ligand-protein interactions applying e.g. protein crystallography and isothermal titration calorimetry. The ultimate goal is the identification of peptidomimetics that allow a targeting of protein so far considered “undruggable”.