Molecular Toxicology

Research profile

Paul_Jennings       Vermeulen
Prof. Paul Jennings          Prof. Nico Vermeulen     

The mission of the Molecular Toxicology research group is to develop novel and innovative concepts concerning drug disposition and drug safety. Integration of advanced computational and experimental approaches is the key, while the focus is on molecular mechanisms of biotransformation, bioactivation and adverse drug reactions.

Our research involves Cytochromes P450 (CYPs, P450s), Glutathione S-transferases (GSTs) and other selected drug targets. Currently, we focus on three distinct but strongly interrelated research lines:

  • Biotransformation and bioactivation
  • Cellular signalling and toxicity
  • Biomolecular simulation and modeling