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- faculteit der exacte wetenschappen ( farmacochemie )
Prof. dr. Martine Smit studied Pharmacochemistry at VU University Amsterdam and graduated in 1991. She obtained her PhD degree in 1995 at the Division of Molecular Pharmacology on the regulation of histamine receptors. Thereafter, she joined the group of Prof. dr. Iyengar at the Department of Pharmacology at Mount Sinai School of Medicine in New York (United States). As a postdoctoral fellow, her research focused on signal transduction mechanisms related to tumorigenesis.
In 1999, Smit was awarded a fellowship of the Royal Netherlands Academy of Arts and Sciences to establish a new research line on human and viral chemokine receptors. She was awarded the Galenus Research Prize for her work on constitutively active receptors in 2002. In 2004, she obtained a NWO Vidi-grant for her work on HCMV-encoded G-protein coupled receptors.
Smit was appointed the Fenna Diemer Lindeboom chair within the Faculty of Science at VU University in 2005 and became head of the Target and Systems Biochemistry research group in 2006. In 2007, she was awarded the Organon Award for Pharmacology. Smit’s research interests are directed at novel concepts of G-protein coupled receptors (e.g. ligand-biased agonism and heterodimerization) and understanding of oncogenic signaling networks activated by histamine and virally encoded chemokine receptors using a systems biology approach. In 2014 she obtained a NWO Vici grant Viral GPCRs in brain cancer: from molecular networks to new therapeutic targets to expand her work on viral GPCRs.