AIMMS Seminar: Dr Daniela Ferreira

05/30/2017

13.00 - 14.00h

Auditorium, O|2 Lab Building

AIMMS Seminar: Using controlled human infection to test new vaccines against the pneumococcus

Dr Daniela Ferreira (Liverpool School of Tropical Medicine, Liverpool, United Kingdom)

Amsterdam Institute for Molecules, Medicines and Systems

Sciences

Seminar

Dr Daniela Ferreira (Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom) will provide an AIMMS Seminar on 30 May entitled 'Using controlled human infection to test new vaccines against the pneumococcus'.

You are all cordially invited!

Abstract

An important paradox in pneumococcal infection, is that in most people pneumococci are only found harmlessly inhabiting in the nasopharynx. This common harmless state, termed pneumococcal carriage, boosts immunity to pneumococcal disease and is therefore of some benefit to the individual.  As pneumococcal carriage is the means by which infection is transmitted, however, it poses a community threat.  Recently acquired bacteria can lead to infection.  Control of pneumococcal carriage is considered to be the key in controlling disease as it is the means of transmission and the prerequisite of disease.

We have established a method, unique in the world, for infecting humans safely with live bacteria in order to establish carriage experimentally, we have now challenged over 800 subjects without adverse effects. This Experimental Human Pneumococcal Carriage (EHPC) model is useful to both understand how healthy subjects make immune responses to carriage and why some subjects with risk factors (age, chronic lung disease) are more susceptible to disease as well as a way to test new vaccines. Testing new vaccines using EHPC can be done more quickly and at a fraction of the cost of clinical studies.