AIMMS Seminar: Dr Francesco Mutti
16.00 - 17.00h
Auditorium, O|2 Lab Building
AIMMS Seminar: In vitro biocatalytic pathway design for the synthesis of high value, optically active molecules
Dr Francesco Mutti (Biocatalysis, HIMS, UvA)
Amsterdam Institute for Molecules, Medicines and Systems
Dr Francesco Mutti (Biocatalysis, HIMS, UvA) will provide an AIMMS Seminar on 23 May entitled 'In vitro biocatalytic pathway design for the synthesis of high value, optically active molecules'.
You are all cordially invited! Drinks afterwards.
This lecture will present recent results from my group on the creation of artificial enzymatic networks for the conversion of inexpensive starting material into valuable and optically active chemical products. Selected examples are: i) the asymmetric biocatalytic synthesis of amines starting from alcohols; ii) the synthesis of α-chiral substituted carboxylic acids from α,β unsaturated aldehydes and ii) the stereoselective di-hydroxylation of alkenes. The properties of a number of enzymes employed in the artificial biocatalytic networks have been modified by my group via structural-guided enzyme engineering. This important aspect will be also discussed.
Dr Francesco Mutti
Francesco Mutti is native of Bergamo (Italy). He obtained a Master’s degree with summa cum laude in Industrial Chemistry (2004) and a PhD in Chemistry (2008) at the University of Milan for his work on the catalytic properties of laccases. From 2009 to 2012, he conducted research on chemo-enzymatic cascades and asymmetric enzymatic reductive amination as Post-Doc in the group of Prof. Wolfgang Kroutil, at the University of Graz (Austria). After a period as Post-Doc in the group of Prof. Nick Turner (2013-2014), Francesco became Research Fellow at The University of Manchester (UK). Since July 2015, Francesco has moved to the University of Amsterdam (NL) to take a tenure-track position as chair of the Biocatalysis group.
Francesco has been recipient of prestigious European grants (e.g. Marie Curie fellowship in 2009 and an ERC Starting Grant in 2014) as well as national Dutch grants (e.g. NWO-Echo and NWO-Sector Plan for Chemistry). He has published more than 30 research papers on international peer-reviewed journals, several book chapters and 3 world patents. Among the others, Francesco was recipient of the “Italian Chemical Society Award 2005” (Italian Chemical Society), he is Honorary Research Fellow of The University of Manchester (2015) and member of the Holland Research School of Molecular Chemistry (2015).
Recent key publications:
1) Knaus, T.; Böhmer, W.; Mutti, F. G.;* “Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds” Green Chem.,2017, 19, 453-463.
2) Mutti, F. G.;* Knaus, T.; Scrutton, N. S.; Breuer, M.; Turner, N. J; “Conversion of alcohols to enantiopure amines through dual enzyme hydrogen-borrowing cascades” Science, 2015, 359, 1525-1529
3) Knaus, T.; Paul, C. E.; Levy, C.W.; de Vries, S.; Mutti, F. G.; Hollmann, F.; Scrutton, N.S.; “Better than nature: Nicotinamide biomimetics that outperform natural coenzymes” J. Am. Chem. Soc., 2016, 138, 1033-1039.
4) Both, P.; Busch, H.; Kelly, P. P.; Mutti, F. G.; Turner, N. J.; Flitsch, S. L.; “Whole-cell biocatalysts for stereoselective C-H amination reactions” Angew. Chem. Int. Ed., 2016, 55, 1511-1513.